Anti-V3 Monoclonal Antibodies Display Broad Neutralizing Activities against Multiple HIV-1 Subtypes

BACKGROUND: The V3 loop of the HIV-1 envelope (Env) glycoprotein gp120 was identified as the “principal neutralizing domain” of HIV-1, but has been considered too variable to serve as a neutralizing antibody (Ab) target. Structural and immunochemical data suggest, however, that V3 contains conserved...

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Detalhes bibliográficos
Main Authors: Hioe, Catarina E., Wrin, Terri, Seaman, Michael S., Yu, Xuesong, Wood, Blake, Self, Steve, Williams, Constance, Gorny, Miroslaw K., Zolla-Pazner, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858080/
https://ncbi.nlm.nih.gov/pubmed/20421997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010254
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