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How does SIRT1 affect metabolism, senescence and cancer?
SIRT1 is a multifaceted, NAD(+)-dependent protein deacetylase that is involved in a wide variety of cellular processes from cancer to ageing. The function of SIRT1 in cancer is complex: SIRT1 has been shown to have oncogenic properties by downregulating p53 activity, but recent studies indicate that...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857763/ https://ncbi.nlm.nih.gov/pubmed/19132007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2562 |
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