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Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence
The proinflammatory cytokine tumor necrosis factor α (TNFα) inhibits hematopoietic stem cell (HSC) expansion, interferes with HSC self-renewal and compromises the ability of HSC to reconstitute hematopoiesis. We have investigated mechanisms by which TNFα suppresses hematopoiesis using the genomic in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857731/ https://ncbi.nlm.nih.gov/pubmed/17405815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.003152 |
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