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Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence

The proinflammatory cytokine tumor necrosis factor α (TNFα) inhibits hematopoietic stem cell (HSC) expansion, interferes with HSC self-renewal and compromises the ability of HSC to reconstitute hematopoiesis. We have investigated mechanisms by which TNFα suppresses hematopoiesis using the genomic in...

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Bibliografische gegevens
Hoofdauteurs: Zhang, Xiaoling, Sejas, Daniel P., Qiu, Yuhui, Williams, David A., Pang, Qishen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857731/
https://ncbi.nlm.nih.gov/pubmed/17405815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.003152
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