TNF-α induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells

The molecular pathogenesis of the myeloid leukemias that frequently occur in patients with Fanconi anemia (FA) is not well defined. Hematopoietic stem cells bearing inactivating mutations of FA complementation group C (FANCC) are genetically unstable and hypersensitive to apoptotic cytokine cues inc...

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Detalhes bibliográficos
Main Authors: Li, June, Sejas, Daniel P., Zhang, Xiaoling, Qiu, Yuhui, Nattamai, Kalpana J., Rani, Reena, Rathbun, Keaney R., Geiger, Hartmut, Williams, David A., Bagby, Grover C., Pang, Qishen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040318/
https://ncbi.nlm.nih.gov/pubmed/17960249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31772
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