TNF-α induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells

The molecular pathogenesis of the myeloid leukemias that frequently occur in patients with Fanconi anemia (FA) is not well defined. Hematopoietic stem cells bearing inactivating mutations of FA complementation group C (FANCC) are genetically unstable and hypersensitive to apoptotic cytokine cues inc...

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Bibliografiske detaljer
Main Authors: Li, June, Sejas, Daniel P., Zhang, Xiaoling, Qiu, Yuhui, Nattamai, Kalpana J., Rani, Reena, Rathbun, Keaney R., Geiger, Hartmut, Williams, David A., Bagby, Grover C., Pang, Qishen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040318/
https://ncbi.nlm.nih.gov/pubmed/17960249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31772
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