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Key residues on microtubule responsible for activation of kinesin ATPase

Microtubule (MT) binding accelerates the rate of ATP hydrolysis in kinesin. To understand the underlying mechanism, using charged-to-alanine mutational analysis, we identified two independent sites in tubulin, which are critical for kinesin motility, namely, a cluster of negatively charged residues...

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Main Authors: Uchimura, Seiichi, Oguchi, Yusuke, Hachikubo, You, Ishiwata, Shin'ichi, Muto, Etsuko
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857467/
https://ncbi.nlm.nih.gov/pubmed/20224548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.25
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