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Key residues on microtubule responsible for activation of kinesin ATPase
Microtubule (MT) binding accelerates the rate of ATP hydrolysis in kinesin. To understand the underlying mechanism, using charged-to-alanine mutational analysis, we identified two independent sites in tubulin, which are critical for kinesin motility, namely, a cluster of negatively charged residues...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857467/ https://ncbi.nlm.nih.gov/pubmed/20224548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.25 |
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