Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function

Sirt1, a NAD-dependent protein deacetylase, is reported to regulate intracellular metabolism and attenuate reactive oxidative species (ROS)-induced apoptosis leading to longevity and acute stress resistance. We created transgenic (TG) mice with kidney-specific overexpression of Sirt1 using the promo...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Hasegawa, Kazuhiro, Wakino, Shu, Yoshioka, Kyoko, Tatematsu, Satoru, Hara, Yoshikazu, Minakuchi, Hitoshi, Sueyasu, Keiko, Washida, Naoki, Tokuyama, Hirobumi, Tzukerman, Maty, Skorecki, Karl, Hayashi, Koichi, Itoh, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857112/
https://ncbi.nlm.nih.gov/pubmed/20139070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.067728
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi