Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function

Sirt1, a NAD-dependent protein deacetylase, is reported to regulate intracellular metabolism and attenuate reactive oxidative species (ROS)-induced apoptosis leading to longevity and acute stress resistance. We created transgenic (TG) mice with kidney-specific overexpression of Sirt1 using the promo...

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Detalhes bibliográficos
Main Authors: Hasegawa, Kazuhiro, Wakino, Shu, Yoshioka, Kyoko, Tatematsu, Satoru, Hara, Yoshikazu, Minakuchi, Hitoshi, Sueyasu, Keiko, Washida, Naoki, Tokuyama, Hirobumi, Tzukerman, Maty, Skorecki, Karl, Hayashi, Koichi, Itoh, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857112/
https://ncbi.nlm.nih.gov/pubmed/20139070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.067728
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