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Anti-HIV Activity of Defective Cyanovirin-N Mutants Is Restored by Dimerization
Cyanovirin-N (CV-N) is a two-domain, cyanobacterial protein that inhibits human immunodeficiency virus (HIV) at nanomolar concentrations by binding to high mannose sugars on the HIV envelope glycoprotein gp120. The wild type protein can exist as a monomer or a domain-swapped dimer with the monomer a...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857066/ https://ncbi.nlm.nih.gov/pubmed/20147291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094938 |
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