Phosphorylation of TRPC6 Channels at Thr(69) Is Required for Anti-hypertrophic Effects of Phosphodiesterase 5 Inhibition

Activation of Ca(2+) signaling induced by receptor stimulation and mechanical stress plays a critical role in the development of cardiac hypertrophy. A canonical transient receptor potential protein subfamily member, TRPC6, which is activated by diacylglycerol and mechanical stretch, works as an ups...

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Main Authors: Nishida, Motohiro, Watanabe, Kenta, Sato, Yoji, Nakaya, Michio, Kitajima, Naoyuki, Ide, Tomomi, Inoue, Ryuji, Kurose, Hitoshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857061/
https://ncbi.nlm.nih.gov/pubmed/20177073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074104
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