Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing

Cellular oxygen sensing is required for hypoxia-inducible factor-1α stabilization, which is important for tumor cell survival, proliferation, and angiogenesis. Here we find that terpestacin, a small molecule previously identified in a screen of microbial extracts, binds to the 13.4-kDa subunit (UQCR...

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Detalhes bibliográficos
Main Authors: Jung, Hye Jin, Shim, Joong Sup, Lee, Jiyong, Song, Young Mi, Park, Ki Chung, Choi, Seung Hoon, Kim, Nam Doo, Yoon, Jeong Hyeok, Mungai, Paul T., Schumacker, Paul T., Kwon, Ho Jeong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857036/
https://ncbi.nlm.nih.gov/pubmed/20145250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.087809
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