Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing

Cellular oxygen sensing is required for hypoxia-inducible factor-1α stabilization, which is important for tumor cell survival, proliferation, and angiogenesis. Here we find that terpestacin, a small molecule previously identified in a screen of microbial extracts, binds to the 13.4-kDa subunit (UQCR...

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Detaylı Bibliyografya
Asıl Yazarlar: Jung, Hye Jin, Shim, Joong Sup, Lee, Jiyong, Song, Young Mi, Park, Ki Chung, Choi, Seung Hoon, Kim, Nam Doo, Yoon, Jeong Hyeok, Mungai, Paul T., Schumacker, Paul T., Kwon, Ho Jeong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857036/
https://ncbi.nlm.nih.gov/pubmed/20145250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.087809
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