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Ubiquitin C-terminal Hydrolase-L1 Protects Cystic Fibrosis Transmembrane Conductance Regulator from Early Stages of Proteasomal Degradation

ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) degradation involves ubiquitin modification and efficient proteasomal targeting of the nascent misfolded protein. We show that a deubiquitinating enzyme, ubiquitin C-terminal hydrolase-L1 (UCH-L1), is highly expressed in cystic fibrosi...

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書目詳細資料
Main Authors: Henderson, Mark J., Vij, Neeraj, Zeitlin, Pamela L.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857010/
https://ncbi.nlm.nih.gov/pubmed/20147297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.044057
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