Ubiquitin C-terminal Hydrolase-L1 Protects Cystic Fibrosis Transmembrane Conductance Regulator from Early Stages of Proteasomal Degradation

ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) degradation involves ubiquitin modification and efficient proteasomal targeting of the nascent misfolded protein. We show that a deubiquitinating enzyme, ubiquitin C-terminal hydrolase-L1 (UCH-L1), is highly expressed in cystic fibrosi...

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Detalhes bibliográficos
Main Authors: Henderson, Mark J., Vij, Neeraj, Zeitlin, Pamela L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857010/
https://ncbi.nlm.nih.gov/pubmed/20147297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.044057
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