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Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: Proteins implicated in pre-mRNA splicing

Yeast and human Tgs1 are orthologous RNA cap (guanine-N2) methyltransferases that convert m(7)G caps into the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal snRNAs. TMG caps are dispensable for vegetative yeast growth, but are essential in the absence of Mud2, the putative yeast...

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Bibliografiske detaljer
Main Authors: Chang, Jonathan, Schwer, Beate, Shuman, Stewart
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856874/
https://ncbi.nlm.nih.gov/pubmed/20360394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2082610
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