Genetic and Biochemical Analysis of Yeast and Human Cap Trimethylguanosine Synthase: FUNCTIONAL OVERLAP OF 2,2,7-TRIMETHYLGUANOSINE CAPS, SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENTS, PRE-mRNA SPLICING FACTORS, AND RNA DECAY PATHWAYS

Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs. Fungi and mammalian somatic cells are able to grow in the absence of Tgs1 and TMG caps, suggesting that an essential functi...

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מידע ביבליוגרפי
Main Authors: Hausmann, Stéphane, Zheng, Sushuang, Costanzo, Michael, Brost, Renee L., Garcin, Dominique, Boone, Charles, Shuman, Stewart, Schwer, Beate
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2008
נושאים:
RNA: Processing and Catalysis
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581544/
https://ncbi.nlm.nih.gov/pubmed/18775984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806127200
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