Genetic and Biochemical Analysis of Yeast and Human Cap Trimethylguanosine Synthase: FUNCTIONAL OVERLAP OF 2,2,7-TRIMETHYLGUANOSINE CAPS, SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENTS, PRE-mRNA SPLICING FACTORS, AND RNA DECAY PATHWAYS

Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs. Fungi and mammalian somatic cells are able to grow in the absence of Tgs1 and TMG caps, suggesting that an essential functi...

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Detalhes bibliográficos
Main Authors: Hausmann, Stéphane, Zheng, Sushuang, Costanzo, Michael, Brost, Renee L., Garcin, Dominique, Boone, Charles, Shuman, Stewart, Schwer, Beate
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
RNA: Processing and Catalysis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581544/
https://ncbi.nlm.nih.gov/pubmed/18775984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806127200
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