Genetic and Biochemical Analysis of Yeast and Human Cap Trimethylguanosine Synthase: FUNCTIONAL OVERLAP OF 2,2,7-TRIMETHYLGUANOSINE CAPS, SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENTS, PRE-mRNA SPLICING FACTORS, AND RNA DECAY PATHWAYS

Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs. Fungi and mammalian somatic cells are able to grow in the absence of Tgs1 and TMG caps, suggesting that an essential functi...

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Autors principals: Hausmann, Stéphane, Zheng, Sushuang, Costanzo, Michael, Brost, Renee L., Garcin, Dominique, Boone, Charles, Shuman, Stewart, Schwer, Beate
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
RNA: Processing and Catalysis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581544/
https://ncbi.nlm.nih.gov/pubmed/18775984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806127200
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