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c-Myb promotes the survival of CD4+CD8+ double positive thymocytes through up-regulation of Bcl-xL

Mechanisms that regulate the lifespan of CD4(+)CD8(+) double positive (DP) thymocytes help shape the peripheral T cell repertoire. However, the molecular mechanisms that control DP thymocyte survival remain poorly understood. The Myb proto-oncogene encodes a transcription factor required during mult...

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Bibliographic Details
Main Authors: Yuan, Joan, Crittenden, Rowena B., Bender, Timothy P.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856624/
https://ncbi.nlm.nih.gov/pubmed/20142358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902846
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