PARP-2 deficiency affects the survival of CD4(+)CD8(+) double-positive thymocytes

Poly-(ADP-ribose) polymerase-2 (PARP-2) belongs to a large family of enzymes that synthesize and transfer ADP-ribose polymers to acceptor proteins, modifying their functional properties. PARP-2-deficient (Parp-2(−/−)) cells, similar to Parp-1(−/−) cells, are sensitive to both ionizing radiation and...

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Autori principali: Yélamos, José, Monreal, Yolanda, Saenz, Luis, Aguado, Enrique, Schreiber, Valérie, Mota, Rubén, Fuente, Teodomiro, Minguela, Alfredo, Parrilla, Pascual, de Murcia, Gilbert, Almarza, Elena, Aparicio, Pedro, Ménissier-de Murcia, Josiane
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1570435/
https://ncbi.nlm.nih.gov/pubmed/16946705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601301
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