PARP-2 deficiency affects the survival of CD4(+)CD8(+) double-positive thymocytes

Poly-(ADP-ribose) polymerase-2 (PARP-2) belongs to a large family of enzymes that synthesize and transfer ADP-ribose polymers to acceptor proteins, modifying their functional properties. PARP-2-deficient (Parp-2(−/−)) cells, similar to Parp-1(−/−) cells, are sensitive to both ionizing radiation and...

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Bibliographic Details
Main Authors:	Yélamos, José, Monreal, Yolanda, Saenz, Luis, Aguado, Enrique, Schreiber, Valérie, Mota, Rubén, Fuente, Teodomiro, Minguela, Alfredo, Parrilla, Pascual, de Murcia, Gilbert, Almarza, Elena, Aparicio, Pedro, Ménissier-de Murcia, Josiane
Format:	Artigo
Language:	Inglês
Published:	2006
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1570435/ https://ncbi.nlm.nih.gov/pubmed/16946705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601301
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PARP-2 deficiency affects the survival of CD4(+)CD8(+) double-positive thymocytes

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