Bcl-xL overexpression decreases GILZ levels and inhibits glucocorticoid-induced activation of caspase-8 and caspase-3 in mouse thymocytes

Glucocorticoids promote thymocyte apoptosis and modulate transcription of numerous regulators of thymic apoptosis. Among these, glucocorticoid-induced leucine zipper (GILZ) is strongly upregulated in the thymus. We have previously demonstrated that GILZ decreases Bcl-xL expression, activates caspase...

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Detalhes bibliográficos
Publicado no:J Transl Autoimmun
Main Authors: Muscari, Isabella, Adorisio, Sabrina, Liberati, Anna Marina, Thuy, Trinh Thi, Van Sung, Tran, Cannarile, Lorenza, Ayroldi, Emira, Riccardi, Carlo, Delfino, Domenico V.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7423577/
https://ncbi.nlm.nih.gov/pubmed/32803151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtauto.2020.100035
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