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Early Intermediate in Human Prion Protein Folding as Evidenced by Ultrarapid Mixing Experiments

An important step towards understanding the mechanism of the PrP(C) to PrP(Sc) conversion is to elucidate the folding pathway(s) of the prion protein. Based on stopped-flow measurements, we recently proposed that the prion protein folds via a transient intermediate formed on the sub-millisecond time...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Apetri, Adrian C., Maki, Kosuke, Roder, Heinrich, Surewicz, Witold K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856597/
https://ncbi.nlm.nih.gov/pubmed/16939293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja063880b
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