Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined Apc(Min )and KRAS(V12 )mutations

BACKGROUND: Both mutational inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene and activation of the KRAS oncogene are implicated in the pathogenesis of colorectal cancer. Mice harboring a germline Apc(Min )mutation or intestine-specific expression of the KRAS(V12 )gene have...

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Hlavní autoři: Nandan, Mandayam O, Ghaleb, Amr M, McConnell, Beth B, Patel, Nilesh V, Robine, Sylvie, Yang, Vincent W
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856552/
https://ncbi.nlm.nih.gov/pubmed/20298593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-63
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