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Suppression of Cancer Cell Growth by Promoting Cyclin D1 Degradation
The cyclin D1 proto-oncoprotein is a crucial regulator in cell cycle progression and aberrant overexpression of cyclin D1 is linked to tumorigenesis of many different cancer types. By screening ubiquitinated cyclin D1 as a substrate with a deubiquitinase library, we have identified USP2 as a specifi...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856324/ https://ncbi.nlm.nih.gov/pubmed/19917254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.10.018 |
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