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Suppression of Cancer Cell Growth by Promoting Cyclin D1 Degradation

The cyclin D1 proto-oncoprotein is a crucial regulator in cell cycle progression and aberrant overexpression of cyclin D1 is linked to tumorigenesis of many different cancer types. By screening ubiquitinated cyclin D1 as a substrate with a deubiquitinase library, we have identified USP2 as a specifi...

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Bibliografiske detaljer
Main Authors: Shan, Jing, Zhao, Wenhui, Gu, Wei
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856324/
https://ncbi.nlm.nih.gov/pubmed/19917254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.10.018
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