Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2

Sphingosine 1-phosphate (S1P), a potent sphingolipid mediator produced by sphingosine kinase isoenzymes (SphK1 and SphK2), regulates diverse cellular processes important for breast cancer progression acting in an autocrine and/or paracrine manner. Here we show that SphK1, but not SphK2, increased S1...

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Главные авторы: Takabe, Kazuaki, Kim, Roger H., Allegood, Jeremy C., Mitra, Poulami, Ramachandran, Subramaniam, Nagahashi, Masayuki, Harikumar, Kuzhuvelil B., Hait, Nitai C., Milstien, Sheldon, Spiegel, Sarah
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Lipids
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856255/
https://ncbi.nlm.nih.gov/pubmed/20110355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064162
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