ABCC1-exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1 Shortens Survival of Mice and Patients with Breast Cancer

Sphingosine-1-phosphate (S1P), a bioactive sphingolipid mediator, has been implicated in regulation of many processes important for breast cancer progression. Previously we observed that S1P is exported out of human breast cancer cells by ATP-binding cassette (ABC) transporter ABCC1, but not by ABCB...

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Pubblicato in:Mol Cancer Res
Autori principali: Yamada, Akimitsu, Nagahashi, Masayuki, Aoyagi, Tomoyoshi, Huang, Wei-Ching, Lima, Santiago, Hait, Nitai C., Maiti, Aparna, Kida, Kumiko, Terracina, Krista P., Miyazaki, Hiroshi, Ishikawa, Takashi, Endo, Itaru, Waters, Michael R., Qi, Qianya, Yan, Li, Milstien, Sheldon, Spiegel, Sarah, Takabe, Kazuaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071310/
https://ncbi.nlm.nih.gov/pubmed/29523764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0353
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