Human ELG1 Regulates the Level of Ubiquitinated Proliferating Cell Nuclear Antigen (PCNA) through Its Interactions with PCNA and USP1

The level of monoubiquitinated proliferating cell nuclear antigen (PCNA) is closely linked with DNA damage bypass to protect cells from a high level of mutagenesis. However, it remains unclear how the level of monoubiquitinated PCNA is regulated. Here, we demonstrate that human ELG1 protein, which c...

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Autores principales: Lee, Kyoo-young, Yang, Kailin, Cohn, Martin A., Sikdar, Nilabja, D'Andrea, Alan D., Myung, Kyungjae
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
DNA and Chromosomes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856242/
https://ncbi.nlm.nih.gov/pubmed/20147293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092544
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