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A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival
Rac1 and Rac2 GTPases transduce signals from multiple receptors leading to cell migration, adhesion, proliferation, and survival. In the absence of Rac1 and Rac2, B cell development is arrested at an IgD(−) transitional B cell stage that we term transitional type 0 (T0). We show that T0 cells cannot...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856036/ https://ncbi.nlm.nih.gov/pubmed/20308364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091489 |
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