A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival

Rac1 and Rac2 GTPases transduce signals from multiple receptors leading to cell migration, adhesion, proliferation, and survival. In the absence of Rac1 and Rac2, B cell development is arrested at an IgD(−) transitional B cell stage that we term transitional type 0 (T0). We show that T0 cells cannot...

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Main Authors: Henderson, Robert B., Grys, Katarzyna, Vehlow, Anne, de Bettignies, Carine, Zachacz, Agnieszka, Henley, Tom, Turner, Martin, Batista, Facundo, Tybulewicz, Victor L.J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856036/
https://ncbi.nlm.nih.gov/pubmed/20308364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091489
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