Comparative pharmacokinetics of plasma- and albumin-free recombinant factor VIII in children and adults: the influence of blood sampling schedule on observed age-related differences and implications for dose tailoring

SUMMARY: Background: Dose tailoring of coagulation factors requires reliably estimated and reproducible pharmacokinetics (PK) in the individual patient. Objectives: To investigate the contribution of both biological and methodological factors to the observed variability of factor VIII (FVIII) PK, wi...

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Main Authors: BJÖRKMAN, S, BLANCHETTE, V S, FISCHER, K, OH, M, SPOTTS, G, SCHROTH, P, FRITSCH, S, PATRONE, L, EWENSTEIN, B M, COLLINS, P W
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2010
Fag:
Clinical Haemostasis and Thrombosis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855866/
https://ncbi.nlm.nih.gov/pubmed/20398185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2010.03757.x
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