Phase I study of BAY 94-9027, a PEGylated B-domain-deleted recombinant factor VIII with an extended half-life, in subjects with hemophilia A

BACKGROUND: BAY 94-9027 is a B-domain-deleted recombinant factor VIII (rFVIII) with site-specific attachment of poly(ethylene glycol) that has shown an extended half-life in animal models of hemophilia. OBJECTIVES: To assess the pharmacokinetics and safety of BAY 94-9027 after single and repeated ad...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Thromb Haemost
Auteurs principaux: Coyle, T E, Reding, M T, Lin, J C, Michaels, L A, Shah, A, Powell, J
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2014
Sujets:
Clinical Haemostasis and Thrombosis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265842/
https://ncbi.nlm.nih.gov/pubmed/24843882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12506
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