Prevention and treatment of experimental autoimmune encephalomyelitis with clonotypic CDR3 peptides: CD4(+) FoxP3(+) T-regulatory cells suppress interleukin-2-dependent expansion of myelin basic protein-specific T cells

T-cell receptor (TCR)-derived peptides are recognized by the immune system and are capable of modulating autoimmune responses. Using the myelin basic protein (MBP) TCR 1501 transgenic mouse model, we demonstrated that TCR CDR3 peptides from the transgenic TCR can provide a protective effect when the...

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Detalhes bibliográficos
Main Authors: Buenafe, Abigail C, Andrew, Shayne, Afentoulis, Michael, Offner, Halina, Vandenbark, Arthur A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855799/
https://ncbi.nlm.nih.gov/pubmed/20059576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2009.03218.x
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