Podocytic PKC-Alpha Is Regulated in Murine and Human Diabetes and Mediates Nephrin Endocytosis

BACKGROUND: Microalbuminuria is an early lesion during the development of diabetic nephropathy. The loss of high molecular weight proteins in the urine is usually associated with decreased expression of slit diaphragm proteins. Nephrin, is the major component of the glomerular slit diaphragm and los...

Full description

Saved in:

Bibliographic Details
Main Authors:	Tossidou, Irini, Teng, Beina, Menne, Jan, Shushakova, Nelli, Park, Joon-Keun, Becker, Jan U., Modde, Friedrich, Leitges, Michael, Haller, Hermann, Schiffer, Mario
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2010
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2855708/ https://ncbi.nlm.nih.gov/pubmed/20419132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010185
Tags:	Add Tag No Tags, Be the first to tag this record!

Podocytic PKC-Alpha Is Regulated in Murine and Human Diabetes and Mediates Nephrin Endocytosis

Similar Items