Podocytic PKC-Alpha Is Regulated in Murine and Human Diabetes and Mediates Nephrin Endocytosis

BACKGROUND: Microalbuminuria is an early lesion during the development of diabetic nephropathy. The loss of high molecular weight proteins in the urine is usually associated with decreased expression of slit diaphragm proteins. Nephrin, is the major component of the glomerular slit diaphragm and los...

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Autores principales: Tossidou, Irini, Teng, Beina, Menne, Jan, Shushakova, Nelli, Park, Joon-Keun, Becker, Jan U., Modde, Friedrich, Leitges, Michael, Haller, Hermann, Schiffer, Mario
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855708/
https://ncbi.nlm.nih.gov/pubmed/20419132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010185
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