Podocytic PKC-Alpha Is Regulated in Murine and Human Diabetes and Mediates Nephrin Endocytosis

BACKGROUND: Microalbuminuria is an early lesion during the development of diabetic nephropathy. The loss of high molecular weight proteins in the urine is usually associated with decreased expression of slit diaphragm proteins. Nephrin, is the major component of the glomerular slit diaphragm and los...

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Détails bibliographiques
Auteurs principaux: Tossidou, Irini, Teng, Beina, Menne, Jan, Shushakova, Nelli, Park, Joon-Keun, Becker, Jan U., Modde, Friedrich, Leitges, Michael, Haller, Hermann, Schiffer, Mario
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855708/
https://ncbi.nlm.nih.gov/pubmed/20419132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010185
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