Pancreatic β cells require NeuroD to achieve and maintain functional maturity

NeuroD, an insulin transactivator, is critical for development of the endocrine pancreas, and NeuroD mutations cause MODY6 in humans. To investigate the role of NeuroD in differentiated β cells, we generated mice in which neuroD is deleted in insulin-expressing cells. These mice exhibit severe gluco...

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Détails bibliographiques
Auteurs principaux: Gu, Chunyan, Stein, Gretchen H., Pan, Ning, Goebbels, Sandra, Hörnberg, Hanna, Nave, Klaus-Armin, Herrera, Pedro, White, Peter, Kaestner, Klaus H., Sussel, Lori, Lee, Jacqueline E.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855640/
https://ncbi.nlm.nih.gov/pubmed/20374962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.03.006
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