טוען...
Pancreatic β cells require NeuroD to achieve and maintain functional maturity
NeuroD, an insulin transactivator, is critical for development of the endocrine pancreas, and NeuroD mutations cause MODY6 in humans. To investigate the role of NeuroD in differentiated β cells, we generated mice in which neuroD is deleted in insulin-expressing cells. These mice exhibit severe gluco...
שמור ב:
| Main Authors: | , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2010
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2855640/ https://ncbi.nlm.nih.gov/pubmed/20374962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.03.006 |
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