Pancreatic β cells require NeuroD to achieve and maintain functional maturity

NeuroD, an insulin transactivator, is critical for development of the endocrine pancreas, and NeuroD mutations cause MODY6 in humans. To investigate the role of NeuroD in differentiated β cells, we generated mice in which neuroD is deleted in insulin-expressing cells. These mice exhibit severe gluco...

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Main Authors: Gu, Chunyan, Stein, Gretchen H., Pan, Ning, Goebbels, Sandra, Hörnberg, Hanna, Nave, Klaus-Armin, Herrera, Pedro, White, Peter, Kaestner, Klaus H., Sussel, Lori, Lee, Jacqueline E.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855640/
https://ncbi.nlm.nih.gov/pubmed/20374962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.03.006
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