Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumors (MPNST) are chemoresistant sarcomas with poor 5-year survival that arise in patients with neurofibromatosis type 1 (NF1) or sporadically. We tested three drugs for single and combinatorial effects on collected MPNST cell lines and in MPNST xenografts. The mam...

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Detalhes bibliográficos
Main Authors: Johansson, Gunnar, Mahller, Yonatan Y., Collins, Margaret H., Kim, Mi-Ok, Nobukuni, Takahiro, Perentesis, John, Cripe, Timothy P., Lane, Heidi A., Kozma, Sara C., Thomas, George, Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855168/
https://ncbi.nlm.nih.gov/pubmed/18483311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-2335
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