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Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation

We show that pentaerythritol tetranitrate reductase (PETNR), a member of the ‘ene’ reductase old yellow enzyme family, catalyses the asymmetric reduction of a variety of industrially relevant activated α,β-unsaturated alkenes including enones, enals, maleimides and nitroalkenes. We have rationalised...

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Main Authors: Fryszkowska, Anna, Toogood, Helen, Sakuma, Michiyo, Gardiner, John M., Stephens, Gill M., Scrutton, Nigel S.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854813/
https://ncbi.nlm.nih.gov/pubmed/20396613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.200900603
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