Homeodomain Interacting Protein Kinase 2: A Target for Alzheimer's Beta Amyloid Leading to Misfolded p53 and Inappropriate Cell Survival

BACKGROUND: Homeodomain interacting protein kinase 2 (HIPK2) is an evolutionary conserved serine/threonine kinase whose activity is fundamental in maintaining wild-type p53 function, thereby controlling the destiny of cells when exposed to DNA damaging agents. We recently reported an altered conform...

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Main Authors: Lanni, Cristina, Nardinocchi, Lavinia, Puca, Rosa, Stanga, Serena, Uberti, Daniela, Memo, Maurizio, Govoni, Stefano, D'Orazi, Gabriella, Racchi, Marco
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854690/
https://ncbi.nlm.nih.gov/pubmed/20418953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010171
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