AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

Excitotoxicity after glutamate receptor overactivation induces disturbances in cellular ion gradients, resulting in necrosis or apoptosis. Excitotoxic necrosis is triggered by rapid, irreversible ATP depletion, whereas the ability to recover cellular bioenergetics is suggested to be necessary for th...

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Bibliografiska uppgifter
Huvudupphovsmän: Concannon, Caoimhín G., Tuffy, Liam P., Weisová, Petronela, Bonner, Helena P., Dávila, David, Bonner, Caroline, Devocelle, Marc C., Strasser, Andreas, Ward, Manus W., Prehn, Jochen H.M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2010
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854380/
https://ncbi.nlm.nih.gov/pubmed/20351066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909166
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