AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

Excitotoxicity after glutamate receptor overactivation induces disturbances in cellular ion gradients, resulting in necrosis or apoptosis. Excitotoxic necrosis is triggered by rapid, irreversible ATP depletion, whereas the ability to recover cellular bioenergetics is suggested to be necessary for th...

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Autors principals: Concannon, Caoimhín G., Tuffy, Liam P., Weisová, Petronela, Bonner, Helena P., Dávila, David, Bonner, Caroline, Devocelle, Marc C., Strasser, Andreas, Ward, Manus W., Prehn, Jochen H.M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2010
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854380/
https://ncbi.nlm.nih.gov/pubmed/20351066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909166
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