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Calcium Sensitivity, Force Frequency Relationship and Cardiac Troponin I: Critical Role of PKA and PKC Phosphorylation Sites
Transgenic models with pseudo phosphorylation mutants of troponin I, PKA sites at Ser 22 and 23 (cTnIDD(22,23) mice) or PKC sites at Ser 42 and 44 (cTnIAD(22,23)DD(42,44)) displayed differential force-frequency relationships and afterload relaxation delay in vivo. We hypothesized that cTnI PKA and P...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854165/ https://ncbi.nlm.nih.gov/pubmed/20083117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.01.004 |
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