Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity

Neuronal mechanisms underlying alcohol intoxication are unclear. We find that alcohol impairs motor coordination by enhancing tonic inhibition mediated by a specific subtype of extrasynaptic GABA(A) receptor (GABAR), α6β3δ, expressed exclusively in cerebellar granule cells. In recombinant studies, w...

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Detaylı Bibliyografya
Asıl Yazarlar: Hanchar, H Jacob, Dodson, Paul D, Olsen, Richard W, Otis, Thomas S, Wallner, Martin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2005
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854077/
https://ncbi.nlm.nih.gov/pubmed/15696164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn1398
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