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Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity
Neuronal mechanisms underlying alcohol intoxication are unclear. We find that alcohol impairs motor coordination by enhancing tonic inhibition mediated by a specific subtype of extrasynaptic GABA(A) receptor (GABAR), α6β3δ, expressed exclusively in cerebellar granule cells. In recombinant studies, w...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854077/ https://ncbi.nlm.nih.gov/pubmed/15696164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn1398 |
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