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RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway

Klotho is a recently identified antiaging gene. Brain endothelin-1 (ET1) is important in the regulation of blood pressure (BP). We hypothesized that silence of brain klotho potentiates cold-induced elevation of BP via the endothelin pathway. To silence brain klotho, we constructed adeno-associated v...

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Detalhes bibliográficos
Main Authors: Wang, Xiuqing, Sun, Zhongjie
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853900/
https://ncbi.nlm.nih.gov/pubmed/20086041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00192.2009
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