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RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway
Klotho is a recently identified antiaging gene. Brain endothelin-1 (ET1) is important in the regulation of blood pressure (BP). We hypothesized that silence of brain klotho potentiates cold-induced elevation of BP via the endothelin pathway. To silence brain klotho, we constructed adeno-associated v...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853900/ https://ncbi.nlm.nih.gov/pubmed/20086041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00192.2009 |
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