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Therapeutic Blockade of T Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease

CD4(+) T cell-mediated autoimmune diseases are initiated and maintained by presentation of self-antigen by antigen-presenting cells (APCs) to self-reactive CD4(+) T cells. According to the two-signal hypothesis, activation of a naïve antigen-specific CD4(+) T cell requires stimulation of both the T...

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Bibliografiska uppgifter
Huvudupphovsmän: Podojil, Joseph R., Turley, Danielle M., Miller, Stephen D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853772/
https://ncbi.nlm.nih.gov/pubmed/19065796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-0-387-09789-3_18
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