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Therapeutic Blockade of T Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease
CD4(+) T cell-mediated autoimmune diseases are initiated and maintained by presentation of self-antigen by antigen-presenting cells (APCs) to self-reactive CD4(+) T cells. According to the two-signal hypothesis, activation of a naïve antigen-specific CD4(+) T cell requires stimulation of both the T...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853772/ https://ncbi.nlm.nih.gov/pubmed/19065796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-0-387-09789-3_18 |
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